Signal interference between drugs and metabolites in LC-ESI-MS quantitative analysis and its evaluation strategy

• Main Authors: Fulin Jiang (Author), Jingyu Liu (Author), Yagang Li (Author), Zihan Lu (Author), Qian Liu (Author), Yunhui Xing (Author), Janshon Zhu (Author), Min Huang (Author), Guoping Zhong (Author)
• Format: Book
• Published: Elsevier, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS) is a widely utilized technique for in vivo pharmaceutical analysis. Ionization interference within electrospray ion source, occurring between drugs and metabolites, can lead to signal variations, potentially compromis...