Effects of the peripheral CB1 receptor antagonist JD5037 in mono- and polytherapy with the AMPK activator metformin in a monocrotaline-induced rat model of pulmonary hypertension

• Main Authors: Patryk Remiszewski (Author), Anna Pędzińska-Betiuk (Author), Krzysztof Mińczuk (Author), Eberhard Schlicker (Author), Justyna Klimek (Author), Janusz Dzięcioł (Author), Barbara Malinowska (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pulmonary hypertension (PH) is a disease leading to increased pressure in the pulmonary artery and right heart failure. The adenosine monophosphate-activated protein kinase (AMPK) activator, metformin, has a protective effect against PH. CB1 receptor blockade reduces the number of pathological alter...