Structure-Based Identification of Novel Histone Deacetylase 4 (HDAC4) Inhibitors

• Main Authors: Rupesh Agarwal (Author), Pawat Pattarawat (Author), Michael R. Duff (Author), Hwa-Chain Robert Wang (Author), Jerome Baudry (Author), Jeremy C. Smith (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Histone deacetylases (HDACs) are important cancer drug targets. Existing FDA-approved drugs target the catalytic pocket of HDACs, which is conserved across subfamilies (classes) of HDAC. However, engineering specificity is an important goal. Herein, we use molecular modeling approaches to identify a...