High-Affinity Anti-VISTA Antibody Protects against Sepsis by Inhibition of T Lymphocyte Apoptosis and Suppression of the Inflammatory Response

• Main Authors: Tianzhu Tao (Author), Lulong Bo (Author), Teng Li (Author), Longbao Shi (Author), Hui Zhang (Author), Bo Ye (Author), Yuhai Xu (Author), Qingqing Ma (Author), Xiaoming Deng (Author), Guorong Zhang (Author)
• Format: Book
• Published: Hindawi Limited, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. B7 family members and ligands have been identified as critical checkpoints in orchestrating the immune response during sepsis. V-domain Ig suppressor of T cell activation (VISTA) is a new inhibitory immune checkpoint involved in restraining T cell response. Previous studies demonstrated...