High-Affinity Anti-VISTA Antibody Protects against Sepsis by Inhibition of T Lymphocyte Apoptosis and Suppression of the Inflammatory Response

• Egile Nagusiak: Tianzhu Tao (Egilea), Lulong Bo (Egilea), Teng Li (Egilea), Longbao Shi (Egilea), Hui Zhang (Egilea), Bo Ye (Egilea), Yuhai Xu (Egilea), Qingqing Ma (Egilea), Xiaoming Deng (Egilea), Guorong Zhang (Egilea)
• Formatua: Liburua
• Argitaratua: Hindawi Limited, 2021-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Background. B7 family members and ligands have been identified as critical checkpoints in orchestrating the immune response during sepsis. V-domain Ig suppressor of T cell activation (VISTA) is a new inhibitory immune checkpoint involved in restraining T cell response. Previous studies demonstrated...