Stability and Compatibility Studies of Levothyroxine Sodium in Solid Binary Systems-Instrumental Screening

• Main Authors: Ionuț Ledeți (Author), Mirabela Romanescu (Author), Denisa Cîrcioban (Author), Adriana Ledeți (Author), Gabriela Vlase (Author), Titus Vlase (Author), Oana Suciu (Author), Marius Murariu (Author), Sorin Olariu (Author), Petru Matusz (Author), Valentina Buda (Author), Doina Piciu (Author)
• Format: Book
• Published: MDPI AG, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The influence of excipients on the stability of sodium levothyroxine pentahydrate (LTSS) under ambient conditions and thermal stress was evaluated. Since LTSS is a synthetic hormone with a narrow therapeutic index, the interactions of LTSS with excipients can lead to a drastic diminution of therapeu...