Disubstituted piperazine analogues of trifluoromethylphenylpiperazine and methylenedioxybenzylpiperazine: analytical differentiation and serotonin receptor binding studies

• Main Authors: Jack DeRuiter (Author), Ashleigh Van Cleave (Author), Audinei de Sousa Moura (Author), Younis Abiedalla (Author), C. Randall Clark (Author)
• Format: Book
• Published: Oxford University Press, 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of N,N-disubstituted piperazines were synthesized containing the structural elements of both methylenedioxybenzylpiperazine (MDBP) and trifluoromethylphenylpiperazine (TFMPP) in a single molecule. These six potential designer drug molecules having a regioisomeric relationship were compared...