Renal tubule-specific Atgl deletion links kidney lipid metabolism to glucagon-like peptide 1 and insulin secretion independent of renal inflammation or lipotoxicity

• Main Authors: Maria F. Fernandes (Author), Juan J. Aristizabal-Henao (Author), Phillip M. Marvyn (Author), Iman M'Hiri (Author), Meghan A. Wiens (Author), Monica Hoang (Author), Manuel Sebastian (Author), Renato Nachbar (Author), Philippe St-Pierre (Author), Kalsha Diaguarachchige De Silva (Author), Geoffrey A. Wood (Author), Jamie W. Joseph (Author), Christine A. Doucette (Author), André Marette (Author), Ken D. Stark (Author), Robin E. Duncan (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Lipotoxic injury from renal lipid accumulation in obesity and type 2 diabetes (T2D) is implicated in associated kidney damage. However, models examining effects of renal ectopic lipid accumulation independent of obesity or T2D are lacking. We generated renal tubule-specific adipose trigly...