Design of New Polyaspartamide Copolymers for siRNA Delivery in Antiasthmatic Therapy

• Main Authors: Emanuela Fabiola Craparo (Author), Salvatore Emanuele Drago (Author), Nicolò Mauro (Author), Gaetano Giammona (Author), Gennara Cavallaro (Author)
• Format: Book
• Published: MDPI AG, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Here, a novel protonable copolymer was realized for the production of polyplexes with a siRNA (inhibitor of STAT6 expression in asthma), with the aim of a pulmonary administration. The polycation was synthesized by derivatization of α,β-poly(N-2-hydroxyethyl)<span style="font-variant: small-...