Structural Modifications of 3-Triazeneindoles and Their Increased Activity Against <i>Mycobacterium tuberculosis</i>

• Main Authors: Konstantin B. Majorov (Author), Boris V. Nikonenko (Author), Pavel Yu. Ivanov (Author), Lyudmila N. Telegina (Author), Alexander S. Apt (Author), Valeria S. Velezheva (Author)
• Format: Book
• Published: MDPI AG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We synthesized 100 novel indole-based compounds with polyaza-functionalities, including 3-triazeneindoles, and tested their activity in vitro against laboratory <i>M. tuberculosis</i> H37Rv and clinical izoniazid-resistant CN-40 isolates, using gross and fine titration approaches. Here w...