New quinoxalinone inhibitors targeting secreted phospholipase A2 and α-glucosidase

• Main Authors: Fatmah A. S. Alasmary (Author), Fatima S. Alnahdi (Author), Abir Ben Bacha (Author), Amr M. El-Araby (Author), Nadine Moubayed (Author), Ahmed M. Alafeefy (Author), Moustafa E. El-Araby (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Elevated blood glucose and increased activities of secreted phospholipase A2 (sPLA2) are strongly linked to coronary heart disease. In this report, our goal was to develop small heterocyclic compound that inhibit sPLA2. The title compounds were also tested against α-glucosidase and α-amylase. This a...