The Specificity and Broad Multitarget Properties of Ligands for the Free Fatty Acid Receptors FFA3/GPR41 and FFA2/GPR43 and the Related Hydroxycarboxylic Acid Receptor HCA2/GPR109A

• Main Authors: Egils Bisenieks (Author), Brigita Vigante (Author), Ramona Petrovska (Author), Baiba Turovska (Author), Ruslan Muhamadejev (Author), Vitalijs Soloduns (Author), Astrida Velena (Author), Karlis Pajuste (Author), Luciano Saso (Author), Janis Klovins (Author), Gunars Duburs (Author), Ilona Mandrika (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The paradigm of ligand-receptor interactions postulated as "one compound-one target" has been evolving; a multi-target, pleiotropic approach is now considered to be realistic. Novel series of 1,4,5,6,7,8-hexahydro-5-oxoquinolines, pyranopyrimidines and S-alkyl derivatives of pyranopyrimidi...