Localization of mutant ubiquitin in the brain of a transgenic mouse line with proteasomal inhibition and its validation at specific sites in Alzheimer's disease

• Main Authors: Romina Jozefa Gentier (Author), Bert M. Verheijen (Author), Margherita eZamboni (Author), Maartje M.A. Stroeken (Author), Denise J.H.P. Hermes (Author), Benno eKusters (Author), Harry Wilhelm Maria Steinbusch (Author), David A. Hopkins (Author), Fred W. Van Leeuwen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Loss of protein quality control by the ubiquitin-proteasome system (UPS) during aging is one of the processes putatively contributing to cellular stress and Alzheimer's disease (AD) pathogenesis. Recently, pooled Genome Wide Association Studies (GWAS), pathway analysis and proteomics identified...