Tacrolimus, a calcineurin inhibitor, promotes capsaicin-induced colonic pain in mice

• প্রধান লেখক: Kazuki Matsui (লেখক), Yuka Terada (লেখক), Maho Tsubota (লেখক), Fumiko Sekiguchi (লেখক), Atsufumi Kawabata (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2020-05-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

TRPV1 is phosphorylated and functionally upregulated by protein kinases, and negatively regulated by phosphatases including calcineurin. Since the clinical use of calcineurin-inhibiting immunosuppressants is commonly associated with chronic diarrhea, we examined if tacrolimus, a calcineurin inhibito...