Enhanced Renal Afferent Arteriolar Reactive Oxygen Species and Contractility to Endothelin-1 Are Associated with Canonical Wnt Signaling in Diabetic Mice

• Main Authors: Suping Zhang (Author), Qian Huang (Author), Qiaoling Wang (Author), Qin Wang (Author), Xiaoyun Cao (Author), Liang Zhao (Author), Nan Xu (Author), Zhengbing Zhuge (Author), Jianhua Mao (Author), Xiaodong Fu (Author), Ruisheng Liu (Author), Christopher S. Wilcox (Author), Andreas Patzak (Author), Lingli Li (Author), En Yin Lai (Author)
• Format: Book
• Published: Karger Publishers, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: Canonical Wnt signaling is involved in oxidative stress, vasculopathy and diabetes mellitus but its role in diabetic renal microvascular dysfunction is unclear. We tested the hypothesis that enhanced canonical Wnt signaling in renal afferent arterioles from diabetic mice increases r...