Glucose Uptake in Rat Skeletal Muscle L6 Cells Is Increased by Low-Intensity Electrical Current Through the Activation of the Phosphatidylinositol-3-OH Kinase (PI-3K) / Akt Pathway

• Main Authors: Shuichiro Yano (Author), Saori Morino-Koga (Author), Tatsuya Kondo (Author), Mary Ann Suico (Author), Tomoaki Koga (Author), Yuichiro Shimauchi (Author), Shingo Matsuyama (Author), Tsuyoshi Shuto (Author), Takashi Sato (Author), Eiichi Araki (Author), Hirofumi Kai (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Activation of Akt by insulin is transmitted via phosphatidylinositol-3-OH kinase (PI-3K) and enhances glucose uptake. The PI-3K/Akt signaling is diminished in insulin resistance. Thus, approaches that activate PI-3K/Akt signaling leading to improved glucose uptake may ameliorate hyperglycemia. Here...