Non-Linear Pharmacokinetics of Oral Roscovitine (Seliciclib) in Cystic Fibrosis Patients Chronically Infected with <i>Pseudomonas aeruginosa</i>: A Study on Population Pharmacokinetics with Monte Carlo Simulations

• Váldodahkkit: Cyril Leven (Dahkki), Sacha Schutz (Dahkki), Marie-Pierre Audrezet (Dahkki), Emmanuel Nowak (Dahkki), Laurent Meijer (Dahkki), Tristan Montier (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2020-11-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Roscovitine (Seliciclib), a new protein kinase inhibitor, was administered orally to adult patients with cystic fibrosis for the first time in the ROSCO-CF trial, a dose-escalation, phase IIa, randomized, controlled trial. Extensive pharmacokinetic sampling was performed up to 12 h after the first o...