Non-Linear Pharmacokinetics of Oral Roscovitine (Seliciclib) in Cystic Fibrosis Patients Chronically Infected with <i>Pseudomonas aeruginosa</i>: A Study on Population Pharmacokinetics with Monte Carlo Simulations

• Main Authors: Cyril Leven (Author), Sacha Schutz (Author), Marie-Pierre Audrezet (Author), Emmanuel Nowak (Author), Laurent Meijer (Author), Tristan Montier (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Roscovitine (Seliciclib), a new protein kinase inhibitor, was administered orally to adult patients with cystic fibrosis for the first time in the ROSCO-CF trial, a dose-escalation, phase IIa, randomized, controlled trial. Extensive pharmacokinetic sampling was performed up to 12 h after the first o...