Downregulation of CYP3A and P-Glycoprotein in the Secondary Inflammatory Response of Mice With Dextran Sulfate Sodium-Induced Colitis and Its Contribution to Cyclosporine A Blood Concentrations

• Egile Nagusiak: Shoji Kawauchi (Egilea), Tsutomu Nakamura (Egilea), Ikuya Miki (Egilea), Jun Inoue (Egilea), Tsuneo Hamaguchi (Egilea), Toshihito Tanahashi (Egilea), Shigeto Mizuno (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2014-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

CYP3A and P-glycoprotein (P-gp) play important roles in drug metabolism and excretion; however, their functions in pathological conditions remain unclear. Hepatobiliary abnormalities have been described in patients with ulcerative colitis, which may affect drug metabolism and excretion in the liver...