Downregulation of CYP3A and P-Glycoprotein in the Secondary Inflammatory Response of Mice With Dextran Sulfate Sodium-Induced Colitis and Its Contribution to Cyclosporine A Blood Concentrations

• Hauptverfasser: Shoji Kawauchi (VerfasserIn), Tsutomu Nakamura (VerfasserIn), Ikuya Miki (VerfasserIn), Jun Inoue (VerfasserIn), Tsuneo Hamaguchi (VerfasserIn), Toshihito Tanahashi (VerfasserIn), Shigeto Mizuno (VerfasserIn)
• Format: Buch
• Veröffentlicht: Elsevier, 2014-01-01T00:00:00Z.
• Schlagworte: article
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CYP3A and P-glycoprotein (P-gp) play important roles in drug metabolism and excretion; however, their functions in pathological conditions remain unclear. Hepatobiliary abnormalities have been described in patients with ulcerative colitis, which may affect drug metabolism and excretion in the liver...