Downregulation of CYP3A and P-Glycoprotein in the Secondary Inflammatory Response of Mice With Dextran Sulfate Sodium-Induced Colitis and Its Contribution to Cyclosporine A Blood Concentrations

Downregulation of CYP3A and P-Glycoprotein in the Secondary Inflammatory Response of Mice With Dextran Sulfate Sodium-Induced Colitis and Its Contribution to Cyclosporine A Blood Concentrations

CYP3A and P-glycoprotein (P-gp) play important roles in drug metabolism and excretion; however, their functions in pathological conditions remain unclear. Hepatobiliary abnormalities have been described in patients with ulcerative colitis, which may affect drug metabolism and excretion in the liver...

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Main Authors: Shoji Kawauchi (Author), Tsutomu Nakamura (Author), Ikuya Miki (Author), Jun Inoue (Author), Tsuneo Hamaguchi (Author), Toshihito Tanahashi (Author), Shigeto Mizuno (Author)
Format: Book
Published: Elsevier, 2014-01-01T00:00:00Z.
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3rd Floor Main Library

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