Statins in Children with Neurofibromatosis Type 1: A Systematic Review of Randomized Controlled Trials

• Main Authors: Aris P. Agouridis (Author), Nikoletta Palli (Author), Vasiliki-Eirini Karagiorga (Author), Afroditi Konsoula (Author), Lamprini Markaki (Author), Nikolaos Spernovasilis (Author), Constantinos Tsioutis (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Statins, apart from their plasma-cholesterol-lowering ability, exert several pleiotropic effects, making them a potential treatment for other diseases. Animal studies have showed that statins, through the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase, can affect the Ras/M...