Search and evaluation of pharmacodynamic and pharmacokinetic parameters of selective blocker of TRPA 1 ion channels from the group of substituted pyrazinopyrimidinones

• Main Authors: Evgeniya А. Beskhmelnitsyna (Author), Dmitriy V. Kravchenko (Author), Lev N. Sernov (Author), Irina N. Dolzhikova (Author), Tatyana V. Avtina (Author), Alexandr L. Kulikov (Author), Darya V. Rozhnova (Author), Vladimir I. Yakushev (Author), Mikhail A. Martynov (Author)
• Format: Book
• Published: Belgorod National Research University, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction. Doctors of almost all specialties have to deal with the problem of pain and its relief. According to the literature, almost 30 million people daily take analgesics from the group of non-opioid analgesics, but in more than half of them 4-6 hours after taking the medication, the severity...