The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice

• Main Authors: Rui Li (Author), Li Xie (Author), Lei Li (Author), Xiaojiao Chen (Author), Tong Yao (Author), Yuanxin Tian (Author), Qingping Li (Author), Kai Wang (Author), Chenyang Huang (Author), Cui Li (Author), Yifan Li (Author), Hongwei Zhou (Author), Neil Kaplowitz (Author), Yong Jiang (Author), Peng Chen (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hepatic ischemia/reperfusion injury (HIRI) is a serious complication that occurs following shock and/or liver surgery. Gut microbiota and their metabolites are key upstream modulators of development of liver injury. Herein, we investigated the potential contribution of gut microbes to HIRI. Ischemia...