Design and Evaluation of Clove Oil-Based Self-Emulsifying Drug Delivery Systems for Improving the Oral Bioavailability of Neratinib Maleate

Design and Evaluation of Clove Oil-Based Self-Emulsifying Drug Delivery Systems for Improving the Oral Bioavailability of Neratinib Maleate

Neratinib maleate (NM), a tyrosine kinase inhibitor, is used in the treatment of breast cancer. NM is orally administered at a high dose of 290 mg due to its low solubility and poor dissolution rate at pH > 3, as well as gut-wall metabolism limiting its bioavailability. Self-emulsifying drug deli...

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Main Authors: Radhika Rajiv Mahajan (Author), Punna Rao Ravi (Author), Riya Kamlesh Marathe (Author), Ajay Gorakh Dongare (Author), Apoorva Vinayak Prabhu (Author), Łukasz Szeleszczuk (Author)
Format: Book
Published: MDPI AG, 2024-08-01T00:00:00Z.
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