Modelling hemodynamics regulation in rats and dogs to facilitate drugs safety risk assessment

• Main Authors: Christopher J. Morris (Author), Michael G. Rolf (Author), Linda Starnes (Author), Inmaculada C. Villar (Author), Amy Pointon (Author), Holly Kimko (Author), Giovanni Y. Di Veroli (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pharmaceutical companies routinely screen compounds for hemodynamics related safety risk. In vitro secondary pharmacology is initially used to prioritize compounds while in vivo studies are later used to quantify and translate risk to humans. This strategy has shown limitations but could be improved...