Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1-BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy

• Main Authors: Xin Yue (Author), Tingyu Liu (Author), Xuecen Wang (Author), Weijian Wu (Author), Gesi Wen (Author), Yang Yi (Author), Jiaxin Wu (Author), Ziyang Wang (Author), Weixiang Zhan (Author), Ruirui Wu (Author), Yuan Meng (Author), Zhirui Cao (Author), Liyuan Le (Author), Wenyan Qiu (Author), Xiaoyue Zhang (Author), Zhenyu Li (Author), Yong Chen (Author), Guohui Wan (Author), Xianzhang Bu (Author), Zhenwei Peng (Author), Ran-yi Liu (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Radiotherapy is widely used in the management of advanced colorectal cancer (CRC). However, the clinical efficacy is limited by the safe irradiated dose. Sensitizing tumor cells to radiotherapy via interrupting DNA repair is a promising approach to conquering the limitation. The BRCA1-BARD1 complex...