A Mutation in IL4RA Is Associated with the Degree of Pathology in Human TB Patients

• Main Authors: Christoph Hölscher (Author), Lisa Heitmann (Author), Ellis Owusu-Dabo (Author), Rolf D. Horstmann (Author), Christian G. Meyer (Author), Stefan Ehlers (Author), Thorsten Thye (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The contribution of interleukin- (IL-) 4 receptor-alpha- (Rα-) dependent events in the pathogenesis of tuberculosis (TB) is controversial. We have recently shown IL-13 overexpression in mice to cause recrudescent Mtb replication and centrally necrotizing granulomas strongly resembling pathology of h...