Rosmarinic acid prevents fibrillization and diminishes vibrational modes associated to β sheet in tau protein linked to Alzheimer's disease

• Main Authors: Alberto Cornejo (Author), Felipe Aguilar Sandoval (Author), Leonardo Caballero (Author), Luis Machuca (Author), Patricio Muñoz (Author), Julio Caballero (Author), George Perry (Author), Alejandro Ardiles (Author), Carlos Areche (Author), Francisco Melo (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease is a common tauopathy where fibril formation and aggregates are the hallmark of the disease. Efforts targeting amyloid-β plaques have succeeded to remove plaques but failed in clinical trials to improve cognition; thus, the current therapeutic strategy is at preventing tau a...