Endoplasmic reticulum-targeted delivery of celastrol and PD-L1 siRNA for reinforcing immunogenic cell death and potentiating cancer immunotherapy

• Main Authors: Jie Wang (Author), Zilong Zhang (Author), Yan Zhuo (Author), Zhuan Zhang (Author), Rongrong Chen (Author), Li Liang (Author), Xiaohe Jiang (Author), Di Nie (Author), Chang Liu (Author), Zhiwen Zou (Author), Xiang Li (Author), Jiaxin Li (Author), Bingqi Wang (Author), Rui Wang (Author), Yong Gan (Author), Miaorong Yu (Author)
• Format: Book
• Published: Elsevier, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The prospect of employing chemoimmunotherapy targeted towards the endoplasmic reticulum (ER) presents an opportunity to amplify the synergistic effects of chemotherapy and immunotherapy. In this study, we initially validated celastrol (CEL) as an inducer of immunogenic cell death (ICD) by promoting...