Novel Characteristics of Trypanosoma brucei Guanosine 5'-monophosphate Reductase Distinct from Host Animals.

• Main Authors: Tomoaki Bessho (Author), Tetsuya Okada (Author), Chihiro Kimura (Author), Takahiro Shinohara (Author), Ai Tomiyama (Author), Akira Imamura (Author), Mitsuru Kuwamura (Author), Kazuhiko Nishimura (Author), Ko Fujimori (Author), Satoshi Shuto (Author), Osamu Ishibashi (Author), Bruno Kilunga Kubata (Author), Takashi Inui (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The metabolic pathway of purine nucleotides in parasitic protozoa is a potent drug target for treatment of parasitemia. Guanosine 5'-monophosphate reductase (GMPR), which catalyzes the deamination of guanosine 5'-monophosphate (GMP) to inosine 5'-monophosphate (IMP), plays an importan...