Targeting Bacterial Cell Division: A Binding Site-Centered Approach to the Most Promising Inhibitors of the Essential Protein FtsZ

• Main Authors: Andrea Casiraghi (Author), Lorenzo Suigo (Author), Ermanno Valoti (Author), Valentina Straniero (Author)
• Format: Bog
• Udgivet: MDPI AG, 2020-02-01T00:00:00Z.
• Fag: article
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Binary fission is the most common mode of bacterial cell division and is mediated by a multiprotein complex denominated the divisome. The constriction of the Z-ring splits the mother bacterial cell into two daughter cells of the same size. The Z-ring is formed by the polymerization of FtsZ, a bacter...