Development of Lentiviral Vectors for HIV-1 Gene Therapy with Vif-Resistant APOBEC3G

• Main Authors: Krista A. Delviks-Frankenberry (Author), Daniel Ackerman (Author), Nina D. Timberlake (Author), Maria Hamscher (Author), Olga A. Nikolaitchik (Author), Wei-Shau Hu (Author), Bruce E. Torbett (Author), Vinay K. Pathak (Author)
• Format: Book
• Published: Elsevier, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Strategies to control HIV-1 replication without antiviral therapy are needed to achieve a functional cure. To exploit the innate antiviral function of restriction factor cytidine deaminase APOBEC3G (A3G), we developed self-activating lentiviral vectors that efficiently deliver HIV-1 Vif-resistant mu...