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Investigation of novel bis-thiadiazole bearing schiff base derivatives as effective inhibitors of thymidine phosphorylase: Synthesis, in vitro bioactivity and molecular docking study

Thymidine phosphorylase (TP) is an angiogenic enzyme. It is crucial for the development, invasion and metastasis of tumors as well as angiogenesis. In our current research, we examine how structurally changing bis-thiadiazole bearing bis-schiff bases affects their ability to inhibit TP. Through the...

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Main Authors: Rafaqat Hussain (Author), Wajid Rehman (Author), Shoaib Khan (Author), Fadi Jaber (Author), Fazal Rahim (Author), Mazloom Shah (Author), Yousaf Khan (Author), Shahid Iqbal (Author), Haseena Naz (Author), Imran Khan (Author), Mohammed Issa Alahmdi (Author), Nasser S. Awwad (Author), Hala A. Ibrahium (Author)
Format: Book
Published: Elsevier, 2023-11-01T00:00:00Z.
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