Construction, Expression, and Characterization of a Recombinant Immunotoxin Targeting EpCAM

• Main Authors: Minghua Lv (Author), Feng Qiu (Author), Tingting Li (Author), Yuanjie Sun (Author), Chunmei Zhang (Author), Ping Zhu (Author), Xiaokun Qi (Author), Jun Wan (Author), Kun Yang (Author), Kui Zhang (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epithelial cell adhesion molecule (EpCAM) is a type I transmembrane glycoprotein overexpressed in human epithelioma but with relatively low expression in normal epithelial tissues. To exploit this differential expression pattern for targeted cancer therapy, an EpCAM-targeted immunotoxin was develope...