Circadian Rhythm Protein Bmal1 Modulates Cartilage Gene Expression in Temporomandibular Joint Osteoarthritis via the MAPK/ERK Pathway

• Main Authors: Guokun Chen (Author), Haoming Zhao (Author), Shixing Ma (Author), Lei Chen (Author), Gaoyi Wu (Author), Yong Zhu (Author), Jie Zhu (Author), Chuan Ma (Author), Huaqiang Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purpose of this study was to elucidate the role of the circadian gene Bmal1 in human cartilage and its crosstalk with the MAPK/ERK signaling pathway in temporomandibular joint osteoarthritis (TMJ-OA). We verified the periodical variation of the circadian gene Bmal1 and then established a modifie...