Synthesis and evaluation of 1, 2, 3-triazole benzoate derivatives for inhibition of serine β-lactamases in extensively drug resistant pathogenic E. coli strains

• Main Authors: Harshal S. Oman (Author), Archana A. Kharat (Author), Pramod S. Phatak (Author), Kishan P. Haval (Author), Jeetendra A. Kulkarni (Author), Ganesh S. Kakde (Author), Kiran R. Kharat (Author), Dilip G. Kadam (Author), Arun S. Kharat (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The β-lactamase enzyme is a leading cause of drug resistance developed by bacteria. The combination of β-lactam (BL) antibiotics with an appropriate β-lactamase inhibitor (BLI) is a fundamental approach used to circumvent the problem of β-lactamase mediated resistance. In the present study, non-repe...