Inhibitory Effect of Zacopride on Cisplatin-Induced Delayed Emesis in Ferrets

• Main Authors: Yamakuni Hisashi (Author), Nakayama Hiroe (Author), Matsui Shigeo (Author), Imazumi Katsunori (Author), Matsuo Masahiko (Author), Mutoh Seitaro (Author)
• Format: Book
• Published: Elsevier, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: We evaluated the antiemetic effect of zacopride, a potent 5-HT3-receptor antagonist with 5-HT4-receptor agonist properties, on delayed emesis caused by cisplatin (5 mg/kg, i.p.) in ferrets, compared with granisetron, a selective 5-HT3-receptor antagonist. Multiple intravenous injections o...