Design, Synthesis and Evaluation of Fused Bicyclo[2.2.2]octene as a Potential Core Scaffold for the Non-Covalent Inhibitors of SARS-CoV-2 3CL^pro Main Protease

• Main Authors: Barbara Herlah (Author), Andrej Hoivik (Author), Luka Jamšek (Author), Katja Valjavec (Author), Norio Yamamoto (Author), Tyuji Hoshino (Author), Krištof Kranjc (Author), Andrej Perdih (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The emergence of SARS-CoV-2, responsible for the global COVID-19 pandemic, requires the rapid development of novel antiviral drugs that would contribute to an effective treatment alongside vaccines. Drug repurposing and development of new molecules targeting numerous viral targets have already led t...