Mutations inside rifampicin-resistance determining region of rpoB gene associated with rifampicin-resistance in Mycobacterium tuberculosis
Background: Rifampicin (RIF) plays a pivotal role in the treatment of tuberculosis due to its bactericidal effects. Because the action of RIF is on rpoB gene encoding RNA polymerase β subunit, 95% of RIF resistant mutations are present in rpoB gene. The majority of the mutations in rpoB gene are fou...
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| Main Authors: | , , |
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| Format: | Book |
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Elsevier,
2018-09-01T00:00:00Z.
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| Summary: | Background: Rifampicin (RIF) plays a pivotal role in the treatment of tuberculosis due to its bactericidal effects. Because the action of RIF is on rpoB gene encoding RNA polymerase β subunit, 95% of RIF resistant mutations are present in rpoB gene. The majority of the mutations in rpoB gene are found within an 81 bp RIF-resistance determining region (RRDR). Methodology: Literatures on RIF resistant mutations published between 2010 and 2016 were thoroughly reviewed. Results: The most commonly mutated codons in RRDR of rpoB gene are 531, 526 and 516. The possibilities of absence of mutation in RRDR of rpoB gene in MDR-TB isolates in few studies was due to existence of other rare rpoB mutations outside RRDR or different mechanism of rifampicin resistance. Conclusion: Molecular methods which can identify extensive mutations associated with multiple anti-tuberculous drugs are in urgent need so that the research on drug resistant mutations should be extended. Keywords: Mutations, Rifampicin-resistance determining region, rpoB gene, Rifampicin resistance, Mycobacterium tuberculosis |
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| Item Description: | 1876-0341 10.1016/j.jiph.2018.04.005 |