Specific and Stable Suppression of HIV Provirus Expression In Vitro by Chimeric Zinc Finger DNA Methyltransferase 1

• Main Authors: Junxiao Deng (Author), Xiying Qu (Author), Panpan Lu (Author), Xinyi Yang (Author), Yuqi Zhu (Author), Haiyan Ji (Author), Yanan Wang (Author), Zhengtao Jiang (Author), Xian Li (Author), Yangcheng Zhong (Author), He Yang (Author), Hanyu Pan (Author), Won-Bin Young (Author), Huanzhang Zhu (Author)
• Format: Book
• Published: Elsevier, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

HIV-1 inserts its proviral DNA into the infected host cells, by which HIV proviral DNA can then be duplicated along with each cell division. Thus, provirus cannot be eradicated completely by current antiretroviral therapy. We have developed an innovative strategy to silence the HIV provirus by targe...