Prevention of Fab-arm exchange and antibody reduction via stabilization of the IgG4 hinge region

• Main Authors: Michael W. Handlogten (Author), Li Peng (Author), Elizabeth A. Christian (Author), Weichen Xu (Author), Shihua Lin (Author), Raghavan Venkat (Author), William Dall'Acqua (Author), Sanjeev Ahuja (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IgG4s are dynamic molecules that undergo a process called Fab-arm exchange. Disulfide bonds between heavy chains are transiently reduced, resulting in half antibodies that reform intact antibodies with other IgG4 half antibodies. In vivo, therapeutic IgG4s can recombine with endogenous IgG4s, result...