Conservation and variability of dengue virus proteins: implications for vaccine design.

• Main Authors: Asif M Khan (Author), Olivo Miotto (Author), Eduardo J M Nascimento (Author), K N Srinivasan (Author), A T Heiny (Author), Guang Lan Zhang (Author), E T Marques (Author), Tin Wee Tan (Author), Vladimir Brusic (Author), Jerome Salmon (Author), J Thomas August (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2008-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Genetic variation and rapid evolution are hallmarks of RNA viruses, the result of high mutation rates in RNA replication and selection of mutants that enhance viral adaptation, including the escape from host immune responses. Variability is uneven across the genome because mutations resulting in a d...