Synthesis, anticancer evaluation and molecular docking studies of new benzimidazole- 1,3,4-oxadiazole derivatives as human topoisomerase types I poison

• Hoofdauteurs: Ulviye Acar Çevik (Auteur), Begüm Nurpelin Sağlık (Auteur), Derya Osmaniye (Auteur), Serkan Levent (Auteur), Betül Kaya Çavuşoğlu (Auteur), Abdullah Burak Karaduman (Auteur), Özlem Atlı Eklioğlu (Auteur), Yusuf Özkay (Auteur), Zafer Asım Kaplancıklı (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

In this study, some benzimidazole-oxadiazole derivatives were synthesised and tested for their in vitro anticancer activities on five cancer cell lines, including HeLa, MCF7, A549, HepG2 and C6. Their structures were elucidated by IR, 1H-NMR, 13C-NMR, 2 D-NMR and HRMS spectroscopic methods. Among al...