Trans-amplifying RNA expressing functional miRNA mediates target gene suppression and simultaneous transgene expression

• Main Authors: Ayşegül Yıldız (Author), Aida Hasani (Author), Tina Hempel (Author), Nina Köhl (Author), Aline Beicht (Author), René Becker (Author), Stefanie Hubich-Rau (Author), Martin Suchan (Author), Marco A. Poleganov (Author), Ugur Sahin (Author), Tim Beissert (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The co-delivery of microRNAs (miRNAs) and protein-coding RNA presents an opportunity for a combined approach to gene expression and gene regulation for therapeutic applications. Protein delivery is established using long mRNA, self-, and trans-amplifying RNA (taRNA), whereas miRNA delivery typically...