Aberrant PRDM2 methylation as an early event in serrated lesions destined to evolve into microsatellite‐instable colorectal cancers

• Main Authors: David EFWM vanToledo (Author), Arne GC Bleijenberg (Author), Andrea Venema (Author), Mireille J deWit (Author), Susanne vanEeden (Author), Gerrit A Meijer (Author), Beatrice Carvalho (Author), Evelien Dekker (Author), Peter Henneman (Author), Joep EG IJspeert (Author), Carel JM vanNoesel (Author)
• Format: Book
• Published: Wiley, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Up to 30% of colorectal cancers (CRCs) develop from sessile serrated lesions (SSLs). Within the serrated neoplasia pathway, at least two principally distinct oncogenetic routes exist generating microsatellite‐stable and microsatellite‐instable CRCs, respectively. Aberrant DNA methylation (D...