Discovery of Novel Inhibitors of Indoleamine 2,3-Dioxygenase 1 Through Structure-Based Virtual Screening

• Principais autores: Guoqing Zhang (Autor), Jing Xing (Autor), Yulan Wang (Autor), Lihao Wang (Autor), Yan Ye (Autor), Dong Lu (Autor), Jihui Zhao (Autor), Xiaomin Luo (Autor), Mingyue Zheng (Autor), Shiying Yan (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Indoleamine 2,3-dioxygenase 1 (IDO1) is an intracellular monomeric heme-containing enzyme that catalyzes the first and the rate limiting step in catabolism of tryptophan via the kynurenine (KYN) pathway, which plays a significant role in the proliferation and differentiation of T cells. IDO1 has bee...