Discovery of Novel Inhibitors of Indoleamine 2,3-Dioxygenase 1 Through Structure-Based Virtual Screening

• Main Authors: Guoqing Zhang (Author), Jing Xing (Author), Yulan Wang (Author), Lihao Wang (Author), Yan Ye (Author), Dong Lu (Author), Jihui Zhao (Author), Xiaomin Luo (Author), Mingyue Zheng (Author), Shiying Yan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Indoleamine 2,3-dioxygenase 1 (IDO1) is an intracellular monomeric heme-containing enzyme that catalyzes the first and the rate limiting step in catabolism of tryptophan via the kynurenine (KYN) pathway, which plays a significant role in the proliferation and differentiation of T cells. IDO1 has bee...