4-Octyl itaconate attenuates glycemic deterioration by regulating macrophage polarization in mouse models of type 1 diabetes

• Main Authors: Sunyue He (Author), Yuchen Zhao (Author), Guoxing Wang (Author), Qiaofang Ke (Author), Nan Wu (Author), Lusi Lu (Author), Jiahua Wu (Author), Shuiya Sun (Author), Weihua Jin (Author), Wenjing Zhang (Author), Jiaqiang Zhou (Author)
• Format: Book
• Published: BMC, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Pancreatic beta cell dysfunction and activated macrophage infiltration are early features in type 1 diabetes pathogenesis. A tricarboxylic acid cycle metabolite that can strongly activate NF-E2-related factor 2 (Nrf2) in macrophages, itaconate is important in a series of inflamma...