Pharmacokinetic Estimation Models-based Approach to Predict Clinical Implications for CYP Induction by Calcitriol in Human Cryopreserved Hepatocytes and HepaRG Cells

• Main Authors: Yoon-Jee Chae (Author), Min-Soo Kim (Author), Suk-Jae Chung (Author), Mi-Kyung Lee (Author), Kyeong-Ryoon Lee (Author), Han-Joo Maeng (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Calcitriol, a vitamin D₃ metabolite, is approved for various indications because it is the bioactive form of vitamin D in the body. The purpose of this study was to predict the clinical significance of cytochrome P450 (CYP) induction by calcitriol using in vitro human cryopres...