Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer

The dose-related adverse effects of MDM2‒P53 inhibitors have caused significant concern in the development of clinical safe anticancer agents. Herein we report an unprecedented homo-PROTAC strategy for more effective disruption of MDM2‒P53 interaction. The design concept is inspired by the capacity...

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Bibliographic Details
Main Authors: Shipeng He (Author), Junhui Ma (Author), Yuxin Fang (Author), Ying Liu (Author), Shanchao Wu (Author), Guoqiang Dong (Author), Wei Wang (Author), Chunquan Sheng (Author)
Format: Book
Published: Elsevier, 2021-06-01T00:00:00Z.
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