Development and Characterization of an Amorphous Solid Dispersion of Furosemide in the Form of a Sublingual Bioadhesive Film to Enhance Bioavailability

• Main Authors: Viviana De Caro (Author), Alessia Ajovalasit (Author), Flavia Maria Sutera (Author), Denise Murgia (Author), Maria Antonietta Sabatino (Author), Clelia Dispenza (Author)
• Format: Book
• Published: MDPI AG, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Administered by an oral route, Furosemide (FUR), a diuretic used in several edematous states and hypertension, presents bioavailability problems, reported as a consequence of an erratic gastrointestinal absorption due to various existing polymorphic forms and low and pH-dependent solubility. A mucoa...