Exploring Kinase Inhibition Properties of 9<i>H</i>-pyrimido[5,4-<i>b</i>]- and [4,5-<i>b</i>]indol-4-amine Derivatives

• Autori principali: Yvonnick Loidreau (Autore), Carole Dubouilh-Benard (Autore), Marie-Renée Nourrisson (Autore), Nadège Loaëc (Autore), Laurent Meijer (Autore), Thierry Besson (Autore), Pascal Marchand (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2020-05-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

We previously highlighted the interest in 6,5,6-fused tricyclic analogues of 4-aminoquinazolines as kinase inhibitors in the micromolar to the nanomolar range of IC₅₀ values. For the generation of chemical libraries, the formamide-mediated cyclization of the cyanoamidine precu...